A set of Tuberculosis gene signatures compiled from various publications. This set of signatures uses gene symbols. Attempts have been made to use updated gene symbols and remove symbols that did not match the most recent annotation. Additional sets for Entrez IDs and Ensembl IDs are forthcoming.
Source
Anderson_42: Anderson, Suzanne T., Myrsini Kaforou, Andrew J. Brent, Victoria J. Wright, Claire M. Banwell, George Chagaluka, Amelia C. Crampin, et al. 2014. "Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa." The New England Journal of Medicine 370 (18): 1712-23. https://dx.doi.org/10.1056/NEJMoa130365710.1056/NEJMoa1303657
Anderson_OD_51: Anderson, Suzanne T., Myrsini Kaforou, Andrew J. Brent, Victoria J. Wright, Claire M. Banwell, George Chagaluka, Amelia C. Crampin, et al. 2014. "Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa." The New England Journal of Medicine 370 (18): 1712-23. https://dx.doi.org/10.1056/NEJMoa130365710.1056/NEJMoa1303657
Berry_393: Berry, Matthew P. R., Christine M. Graham, Finlay W. McNab, Zhaohui Xu, Susannah A. A. Bloch, Tolu Oni, Katalin A. Wilkinson, et al. 2010. "An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis." Nature 466 (7309): 973-77. https://dx.doi.org/10.1038/nature0924710.1038/nature09247
Berry_OD_86: Berry, Matthew P. R., Christine M. Graham, Finlay W. McNab, Zhaohui Xu, Susannah A. A. Bloch, Tolu Oni, Katalin A. Wilkinson, et al. 2010. "An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis." Nature 466 (7309): 973-77. https://dx.doi.org/10.1038/nature0924710.1038/nature09247
Blankley_380: Blankley, Simon, Christine M. Graham, Joe Levin, Jacob Turner, Matthew P. R. Berry, Chloe I. Bloom, Zhaohui Xu, et al. 2016. "A 380-Gene Meta-Signature of Active Tuberculosis Compared with Healthy Controls." The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology 47 (6): 1873-76. https://dx.doi.org/10.1183/13993003.02121-201510.1183/13993003.02121-2015
Blankley_5: Blankley, Simon, Christine M. Graham, Joe Levin, Jacob Turner, Matthew P. R. Berry, Chloe I. Bloom, Zhaohui Xu, et al. 2016. "A 380-Gene Meta-Signature of Active Tuberculosis Compared with Healthy Controls." The European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology 47 (6): 1873-76. https://dx.doi.org/10.1183/13993003.02121-201510.1183/13993003.02121-2015
Bloom_OD_144: Bloom, Chloe I., Christine M. Graham, Matthew P. R. Berry, Fotini Rozakeas, Paul S. Redford, Yuanyuan Wang, Zhaohui Xu, et al. 2013. "Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers." PloS One 8 (8): e70630. https://dx.doi.org/10.1371/journal.pone.007063010.1371/journal.pone.0070630
Bloom_RES_268: Bloom CI, Graham CM, Berry MP, et al. Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PLoS One. 2012;7(10):e46191. https://dx.doi.org/10.3389/fmicb.2021.65056710.3389/fmicb.2021.650567
Bloom_RES_558: Bloom CI, Graham CM, Berry MP, et al. Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PLoS One. 2012;7(10):e46191. https://dx.doi.org/10.3389/fmicb.2021.65056710.3389/fmicb.2021.650567
Chen_5: Chen L, Hua J, He X. Coexpression Network Analysis-Based Identification of Critical Genes Differentiating between Latent and Active Tuberculosis. Dis Markers. 2022;2022:2090560. http://dx.doi.org/10.1155/2022/209056010.1155/2022/2090560
Chen_HIV_4: Chen Y, Wang Q, Lin S, et al. Meta-Analysis of Peripheral Blood Transcriptome Datasets Reveals a Biomarker Panel for Tuberculosis in Patients Infected With HIV. Front Cell Infect Microbiol. 2021;11:585919. Published 2021 Mar 19. https://dx.doi.org/10.3389/fcimb.2021.58591910.3389/fcimb.2021.585919
Chendi_HIV_2: Chendi BH, Tveiten H, Snyders CI, et al. CCL1 and IL-2Ra differentiate Tuberculosis disease from latent infection Irrespective of HIV infection in low TB burden countries. J Infect. 2021;S0163-4453(21)00379-0. https://dx.doi.org/10.1016/j.jinf.2021.07.03610.1016/j.jinf.2021.07.036
Darboe_RISK_11: Darboe, F. et al. Diagnostic performance of an optimized transcriptomic signature of risk of tuberculosis in cryopreserved peripheral blood mononuclear cells. Tuberculosis 108, 124-126 (2018). https://dx.doi.org/ 10.1016/j.tube.2017.11.001 10.1016/j.tube.2017.11.001
Dawany_HIV_251: Dawany, N. et al. Identification of a 251 gene expression signature that can accurately detect M. tuberculosis in patients with and without HIV co-infection. PLoS One 9, (2014). https://dx.doi.org/10.1371/journal.pone.008992510.1371/journal.pone.0089925
Duffy_23: Duffy FJ, Olson GS, Gold ES, Jahn A, Aderem A, Aitchison J, Rothchild AC, Diercks AH, Nemeth J. A contained Mycobacterium tuberculosis mouse infection model predicts active disease and containment in humans. The Journal of Infectious Diseases. 2021 Mar 10. https://dx.doi.org/10.1093/infdis/jiab13010.1093/infdis/jiab130
Esmail_203: Esmail, Hanif, Rachel P. Lai, Maia Lesosky, Katalin A. Wilkinson, Christine M. Graham, Stuart Horswell, Anna K. Coussens, Clifton E. Barry 3rd, Anne O'Garra, and Robert J. Wilkinson. 2018. "Complement Pathway Gene Activation and Rising Circulating Immune Complexes Characterize Early Disease in HIV-Associated Tuberculosis." Proceedings of the National Academy of Sciences of the United States of America 115 (5): E964-73. https://dx.doi.org/10.1073/pnas.171185311510.1073/pnas.1711853115
Esmail_82: Esmail, Hanif, Rachel P. Lai, Maia Lesosky, Katalin A. Wilkinson, Christine M. Graham, Stuart Horswell, Anna K. Coussens, Clifton E. Barry 3rd, Anne O'Garra, and Robert J. Wilkinson. 2018. "Complement Pathway Gene Activation and Rising Circulating Immune Complexes Characterize Early Disease in HIV-Associated Tuberculosis." Proceedings of the National Academy of Sciences of the United States of America 115 (5): E964-73. https://dx.doi.org/10.1073/pnas.171185311510.1073/pnas.1711853115
Esmail_893: Esmail, Hanif, Rachel P. Lai, Maia Lesosky, Katalin A. Wilkinson, Christine M. Graham, Stuart Horswell, Anna K. Coussens, Clifton E. Barry 3rd, Anne O'Garra, and Robert J. Wilkinson. 2018. "Complement Pathway Gene Activation and Rising Circulating Immune Complexes Characterize Early Disease in HIV-Associated Tuberculosis." Proceedings of the National Academy of Sciences of the United States of America 115 (5): E964-73. https://dx.doi.org/10.1073/pnas.171185311510.1073/pnas.1711853115
Estevez_133: Estévez O, Anibarro L, Garet E, et al. An RNA-seq Based Machine Learning Approach Identifies Latent Tuberculosis Patients With an Active Tuberculosis Profile. Front Immunol. 2020;11:1470. Published 2020 Jul 14. https://dx.doi.org/10.3389/fimmu.2020.0147010.3389/fimmu.2020.01470
Estevez_259: Estévez O, Anibarro L, Garet E, et al. An RNA-seq Based Machine Learning Approach Identifies Latent Tuberculosis Patients With an Active Tuberculosis Profile. Front Immunol. 2020;11:1470. Published 2020 Jul 14. https://dx.doi.org/10.3389/fimmu.2020.0147010.3389/fimmu.2020.01470
Francisco_OD_2: Francisco NM, Fang YM, Ding L, et al. Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases. J Infect. 2017;75(6):499-510. http://dx.doi.org/10.1016/j.jinf.2017.09.01210.1016/j.jinf.2017.09.012
Gjoen_10: Gjøen, J.E., Jenum, S., Sivakumaran, D. et al. 'Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children.' Sci Rep 7, 5839 (2017). https://doi.org/10.1038/s41598-017-05057-x10.1038/s41598-017-05057-x
Gjoen_7: Gjøen, J.E., Jenum, S., Sivakumaran, D. et al. 'Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children.' Sci Rep 7, 5839 (2017). https://doi.org/10.1038/s41598-017-05057-x10.1038/s41598-017-05057-x
Gliddon_2_OD_4: Gliddon HD, Kaforou M, Alikian M, et al. Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification. Front Immunol. 2021;12:637164. Published 2021 Mar 2. https://dx.doi.org/10.3389/fimmu.2021.63716410.3389/fimmu.2021.637164
Gliddon_HIV_3: Gliddon HD, Kaforou M, Alikian M, et al. Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification. Front Immunol. 2021;12:637164. Published 2021 Mar 2. https://dx.doi.org/10.3389/fimmu.2021.63716410.3389/fimmu.2021.637164
Gliddon_OD_3: Gliddon, Harriet D., Kaforou, Myrsini, Alikian, Mary, Habgood-Coote, Dominic, Zhou, Chenxi, Oni, Tolu, Anderson, Suzanne T., Brent, Andrew J., Crampin, Amelia C., Eley, Brian, Kern, Florian, Langford, Paul R., Ottenhoff, Tom H. M., Hibberd, Martin L., French, Neil, Wright, Victoria J., Dockrell, Hazel M., Coin, Lachlan J., Wilkinson, Robert J., Levin, Michael. 2019 "Identification of reduced host transcriptomic signatures for tuberculosis and digital PCR-based validation and quantification" biorxiv.org:https://dx.doi.org/10.1101/58367410.1101/583674
Gliddon_OD_4: Gliddon, Harriet D., Kaforou, Myrsini, Alikian, Mary, Habgood-Coote, Dominic, Zhou, Chenxi, Oni, Tolu, Anderson, Suzanne T., Brent, Andrew J., Crampin, Amelia C., Eley, Brian, Kern, Florian, Langford, Paul R., Ottenhoff, Tom H. M., Hibberd, Martin L., French, Neil, Wright, Victoria J., Dockrell, Hazel M., Coin, Lachlan J., Wilkinson, Robert J., Levin, Michael. 2019 "Identification of reduced host transcriptomic signatures for tuberculosis and digital PCR-based validation and quantification" biorxiv.org:https://dx.doi.org/10.1101/58367410.1101/583674
Gong_OD_4: Gong Z, Gu Y, Xiong K, Niu J, Zheng R, Su B, Fan L and Xie J (2021) The Evaluation and Validation of Blood-Derived Novel Biomarkers for Precise and Rapid Diagnosis of Tuberculosis in Areas With High-TB Burden. Front. Microbiol. 12:650567. https://dx.doi.org/10.3389/fmicb.2021.65056710.3389/fmicb.2021.650567
Heycken_FAIL_22: Heyckendorf J, Marwitz S, Reimann M, et al. Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model. Eur Respir J. 2021;2003492. https://dx.doi.org/10.1183/13993003.03492-202010.1183/13993003.03492-2020
Hoang_OD_13: Hoang, Long & Jain, Pooja & Pillay, Timesh & Tolosa-Wright, Mica & Niazi, Umar & Takwoingi, Yemisi & Halliday, Alice & Berrocal-Almanza, Luis & Deeks, Jonathan & Beverley, Peter & Kon, Onn & Lalvani, Ajit. (2021). Transcriptomic signatures for diagnosing tuberculosis in clinical practice: a prospective, multicentre cohort study. The Lancet Infectious Diseases. https://dx.doi.org/10.1016/S1473-3099(20)30928-210.1016/S1473-3099(20)30928-2
Hoang_OD_20: Hoang, Long & Jain, Pooja & Pillay, Timesh & Tolosa-Wright, Mica & Niazi, Umar & Takwoingi, Yemisi & Halliday, Alice & Berrocal-Almanza, Luis & Deeks, Jonathan & Beverley, Peter & Kon, Onn & Lalvani, Ajit. (2021). Transcriptomic signatures for diagnosing tuberculosis in clinical practice: a prospective, multicentre cohort study. The Lancet Infectious Diseases. https://dx.doi.org/10.1016/S1473-3099(20)30928-210.1016/S1473-3099(20)30928-2
Hoang_OD_3: Hoang, Long & Jain, Pooja & Pillay, Timesh & Tolosa-Wright, Mica & Niazi, Umar & Takwoingi, Yemisi & Halliday, Alice & Berrocal-Almanza, Luis & Deeks, Jonathan & Beverley, Peter & Kon, Onn & Lalvani, Ajit. (2021). Transcriptomic signatures for diagnosing tuberculosis in clinical practice: a prospective, multicentre cohort study. The Lancet Infectious Diseases. https://dx.doi.org/10.1016/S1473-3099(20)30928-210.1016/S1473-3099(20)30928-2
Huang_13: Huang, Hai-Hui et al. 'Identification of 13 Blood-based Gene Expression Signatures to Accurately Distinguish Tuberculosis from Other Pulmonary Diseases and Healthy Controls'. 1 Jan. 2015 : S1837 - S1843.https://doi.org/10.3233/BME-15148610.3233/BME-151486
Jacobsen_3: Jacobsen, Marc, Dirk Repsilber, Andrea Gutschmidt, Albert Neher, Knut Feldmann, Hans J. Mollenkopf, Andreas Ziegler, and Stefan H. E. Kaufmann. 2007. "Candidate Biomarkers for Discrimination between Infection and Disease Caused by Mycobacterium Tuberculosis." Journal of Molecular Medicine 85 (6): 613-21. https://dx.doi.org/10.1007/s00109-007-0157-610.1007/s00109-007-0157-6
Jenum_8: Jenum, S., Dhanasekaran, S., Lodha, R. et al. Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum. Sci Rep 6, 18520 (2016). https://doi.org/10.1038/srep1852010.1038/srep18520
Kaforou_27: Kaforou, Myrsini, Victoria J. Wright, Tolu Oni, Neil French, Suzanne T. Anderson, Nonzwakazi Bangani, Claire M. Banwell, et al. 2013. "Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study." PLoS Medicine 10 (10): e1001538. https://dx.doi.org/10.1371/journal.pmed.100153810.1371/journal.pmed.1001538
Kaforou_OD_44: Kaforou, Myrsini, Victoria J. Wright, Tolu Oni, Neil French, Suzanne T. Anderson, Nonzwakazi Bangani, Claire M. Banwell, et al. 2013. "Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study." PLoS Medicine 10 (10): e1001538. https://dx.doi.org/10.1371/journal.pmed.100153810.1371/journal.pmed.1001538
Kaforou_OD_53: Kaforou, Myrsini, Victoria J. Wright, Tolu Oni, Neil French, Suzanne T. Anderson, Nonzwakazi Bangani, Claire M. Banwell, et al. 2013. "Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study." PLoS Medicine 10 (10): e1001538. https://dx.doi.org/10.1371/journal.pmed.100153810.1371/journal.pmed.1001538
Kaul_3: Kaul S, Nair V, Birla S, et al. Latent Tuberculosis Infection Diagnosis among Household Contacts in a High Tuberculosis-Burden Area: a Comparison between Transcript Signature and Interferon Gamma Release Assay. Microbiol Spectr. 2022;10(2):e0244521. http://dx.doi.org/10.1128/spectrum.02445-2110.1128/spectrum.02445-21
Kulkarni_HIV_2: Kulkarni V, Queiroz ATL, Sangle S, et al. A Two-Gene Signature for Tuberculosis Diagnosis in Persons With Advanced HIV. Front Immunol. 2021;12:631165. Published 2021 Feb 22. https://dx.doi.org/10.3389/fimmu.2021.63116510.3389/fimmu.2021.631165
Kwan_186: Kwan PKW, Periaswamy B, De Sessions PF, et al. A blood RNA transcript signature for TB exposure in household contacts. BMC Infect Dis. 2020;20(1):403. http://dx.doi.org/10.1186/s12879-020-05116-110.1186/s12879-020-05116-1
LauxdaCosta_OD_3: Laux da Costa L, Delcroix M, Dalla Costa ER, et al. A real-time PCR signature to discriminate between tuberculosis and other pulmonary diseases. Tuberculosis (Edinb). 2015;95(4):421-425. https://dx.doi.org/10.1016/j.tube.2015.04.00810.1016/j.tube.2015.04.008
Lee_4: Lee, Shih-Wei, Lawrence Shih-Hsin Wu, Guan-Mau Huang, Kai-Yao Huang, Tzong-Yi Lee, and Julia Tzu-Ya Weng. 2016. "Gene Expression Profiling Identifies Candidate Biomarkers for Active and Latent Tuberculosis." BMC Bioinformatics 17 Suppl 1 (January): 3. https://dx.doi.org/10.1186/s12859-015-0848-x10.1186/s12859-015-0848-x
Leong_24: Leong, Samantha, Yue Zhao, Noyal M. Joseph, Natasha S. Hochberg, Sonali Sarkar, Jane Pleskunas, David Hom, et al. 2018. "Existing blood transcriptional classifiers accurately discriminate active tuberculosis from latent infection in individuals from south India." Tuberculosis (109): 41-51. https://doi.org/10.1016/j.tube.2018.01.00210.1016/j.tube.2018.01.002
Leong_RISK_29: Leong, S., Zhao, Y., Ribeiro-Rodrigues, R., Jones-López, E. C., Acuña-Villaorduña, C., Rodrigues, P. M., Palaci, M., Alland, D., Dietze, R., Ellner, J. J., Johnson, W. E., Salgame, P., Cross-validation of existing signatures and derivation of a novel 29-gene transcriptomic signature predictive of progression to TB in a Brazilian cohort of household contacts of pulmonary TB. Tuberculosis (Edinb). 2020 Jan;120:101898. https://dx.doi.org/10.1016/j.tube.2020.10189810.1016/j.tube.2020.101898
Long_RES_10: Long NP, Phat NK, Yen NTH, et al. A 10-gene biosignature of tuberculosis treatment monitoring and treatment outcome prediction. Tuberculosis (Edinb). 2021;131:102138. http://dx.doi.org/10.1016/j.tube.2021.10213810.1016/j.tube.2021.102138
Maertzdorf_15: Maertzdorf J, McEwen G, Weiner J 3rd, et al. Concise gene signature for point-of-care classification of tuberculosis. EMBO Mol Med. 2016;8(2):86-95. https://dx.doi.org/10.15252/emmm.20150579010.15252/emmm.201505790
Maertzdorf_4: Maertzdorf, Jeroen, Gayle McEwen, January Weiner 3rd, Song Tian, Eric Lader, Ulrich Schriek, Harriet Mayanja-Kizza, Martin Ota, John Kenneth, and Stefan He Kaufmann. 2016. "Concise Gene Signature for Point-of-Care Classification of Tuberculosis." EMBO Molecular Medicine 8 (2): 86-95. https://dx.doi.org/10.15252/emmm.20150579010.15252/emmm.201505790
Maertzdorf_OD_100: Maertzdorf, Jeroen, January Weiner 3rd, Hans-Joachim Mollenkopf, TBornot TB Network, Torsten Bauer, Antje Prasse, Joachim Müller-Quernheim, and Stefan H. E. Kaufmann. 2012. "Common Patterns and Disease-Related Signatures in Tuberculosis and Sarcoidosis." Proceedings of the National Academy of Sciences of the United States of America 109 (20): 7853-58. https://dx.doi.org/10.1073/pnas.112107210910.1073/pnas.1121072109
Natarajan_7: Natarajan S, Ranganathan M, Hanna LE, Tripathy S. Transcriptional Profiling and Deriving a Seven-Gene Signature That Discriminates Active and Latent Tuberculosis: An Integrative Bioinformatics Approach. Genes (Basel). 2022;13(4):616. Published 2022 Mar 29. http://dx.doi.org/10.3390/genes1304061610.3390/genes13040616
PennNich_RISK_6: Penn-Nicholson, A. et al. RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response. Sci. Rep. 10, (2020). https://dx.doi.org/10.1038/s41598-020-65043-810.1038/s41598-020-65043-8
Qian_OD_17: Qian, Zhongqing et al. "Expression of nuclear factor, erythroid 2-like 2-mediated genes differentiates tuberculosis." Tuberculosis (Edinburgh, Scotland) vol. 99 (2016): 56-62. https://doi.org/10.1016/j.tube.2016.04.00810.1016/j.tube.2016.04.008
Rajan_HIV_5: Rajan, Jayant V., Semitala, Fred C., Kamya, Moses R., Yoon, Christina., Mehta, Tejas., Cattamanchi, Adithya., Seielstad, Mark., Montalvo, Lani., Andama, Alfred., Katende, Jane., Asege, Lucy., Nakaye, Martha., Mwebe, Sandra. 2018 "A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency Virus" Clinical Infectious Diseases: 1-7. https://doi.org/10.1093/cid/ciy83510.1093/cid/ciy835
Roe_3: Roe, Jennifer, Venturini, Cristina, Gupta, Rishi K., Gurry, Celine, Chain, Benjamin M., Sun, Yuxin, Southern, Jo, Jackson, Charlotte, Lipman, Marc, C., Miller, Robert F., Martineau, Adrian R., Abubakar, Ibrahim, Noursadeghi, Mahdad. 2019 "T1 Blood transcriptomic stratification of short-term risk in contacts of tuberculosis": . https://doi.org/10.1093/cid/ciz25210.1093/cid/ciz252
Roe_OD_4: Roe, Jennifer K., Niclas Thomas, Eliza Gil, Katharine Best, Evdokia Tsaliki, Stephen Morris-Jones, Sian Stafford, et al. 2016. "Blood Transcriptomic Diagnosis of Pulmonary and Extrapulmonary Tuberculosis." JCI Insight 1 (16): e87238. https://dx.doi.org/10.1172/jci.insight.8723810.1172/jci.insight.87238
Sambarey_HIV_10: Sambarey, Awanti, Abhinandan Devaprasad, Abhilash Mohan, Asma Ahmed, Soumya Nayak, Soumya Swaminathan, George D'Souza, et al. 2017. "Unbiased Identification of Blood-Based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks." EBioMedicine 15 (February): 112-26. https://dx.doi.org/10.1016/j.ebiom.2016.12.00910.1016/j.ebiom.2016.12.009
Singhania_OD_20: Singhania, Akul, Raman Verma, Christine M. Graham, Jo Lee, Trang Tran, Matthew Richardson, Patrick Lecine, et al. 2018. "A Modular Transcriptional Signature Identifies Phenotypic Heterogeneity of Human Tuberculosis Infection." Nature Communications 9 (1): 2308. https://dx.doi.org/10.1038/s41467-018-04579-w10.1038/s41467-018-04579-w
Sivakumaran_11: Sivakumaran D, Ritz C, Gjøen JE, et al. Host Blood RNA Transcript and Protein Signatures for Sputum-Independent Diagnostics of Tuberculosis in Adults. Front Immunol. 2021;11:626049. Published 2021 Feb 4. https://dx.doi.org/10.3389/fimmu.2020.62604910.3389/fimmu.2020.626049
Sloot_HIV_2: Sloot, Rosa, Maarten F. Schim van der Loeff, Erik W. van Zwet, Mariëlle C. Haks, Sytze T. Keizer, Maarten Scholing, Tom H. M. Ottenhoff, Martien W. Borgdorff, and Simone A. Joosten. 2015. "Biomarkers Can Identify Pulmonary Tuberculosis in HIV-Infected Drug Users Months Prior to Clinical Diagnosis." EBioMedicine 2 (2): 172-79. https://dx.doi.org/10.1016/j.ebiom.2014.12.00110.1016/j.ebiom.2014.12.001
Suliman_4: Suliman, Sara, Ethan Thompson, Jayne Sutherland, January Weiner Rd, Martin O. C. Ota, Smitha Shankar, Adam Penn-Nicholson, et al. 2018. "Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis." American Journal of Respiratory and Critical Care Medicine, April. https://doi.org/10.1164/rccm.201711-2340OC. https://dx.doi.org/10.1164/rccm.201711-2340OC10.1164/rccm.201711-2340OC
Suliman_RISK_2: Suliman, S. et al. Four-gene pan-African blood signature predicts progression to tuberculosis. Am. J. Respir. Crit. Care Med. 197, 1198-1208 (2018). https://dx.doi.org/10.1164/rccm.201711-2340OC10.1164/rccm.201711-2340OC
Suliman_RISK_4: Suliman, Sara, Ethan Thompson, Jayne Sutherland, January Weiner Rd, Martin O. C. Ota, Smitha Shankar, Adam Penn-Nicholson, et al. 2018. "Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis." American Journal of Respiratory and Critical Care Medicine, April. https://doi.org/10.1164/rccm.201711-2340OC. https://dx.doi.org/10.1164/rccm.201711-2340OC10.1164/rccm.201711-2340OC
Sweeney_OD_3: Sweeney, Timothy E., Lindsay Braviak, Cristina M. Tato, and Purvesh Khatri. 2016. "Genome-Wide Expression for Diagnosis of Pulmonary Tuberculosis: A Multicohort Analysis." The Lancet. Respiratory Medicine 4 (3): 213-24. https://dx.doi.org/10.1016/S2213-2600(16)00048-510.1016/S2213-2600(16)00048-5
Tabone_OD_11: Tabone O, Verma R, Singhania A, et al. Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis. J Exp Med. 2021;218(10):e20210915. http://dx.doi.org/10.1084/jem.2021091510.1084/jem.20210915
Tabone_RES_25: Tabone O, Verma R, Singhania A, et al. Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis. J Exp Med. 2021;218(10):e20210915. http://dx.doi.org/10.1084/jem.2021091510.1084/jem.20210915
Tabone_RES_27: Tabone O, Verma R, Singhania A, et al. Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis. J Exp Med. 2021;218(10):e20210915. http://dx.doi.org/10.1084/jem.2021091510.1084/jem.20210915
Thompson_9: Thompson, Ethan G., Ying Du, Stephanus T. Malherbe, Smitha Shankar, Jackie Braun, Joe Valvo, Katharina Ronacher, et al. 2017. "Host Blood RNA Signatures Predict the Outcome of Tuberculosis Treatment." Tuberculosis 107 (December): 48-58. https://dx.doi.org/10.1016/j.tube.2017.08.00410.1016/j.tube.2017.08.004
Thompson_FAIL_13: Thompson, Ethan G., Ying Du, Stephanus T. Malherbe, Smitha Shankar, Jackie Braun, Joe Valvo, Katharina Ronacher, et al. 2017. "Host Blood RNA Signatures Predict the Outcome of Tuberculosis Treatment." Tuberculosis 107 (December): 48-58. https://dx.doi.org/10.1016/j.tube.2017.08.00410.1016/j.tube.2017.08.004
Thompson_RES_5: Thompson, Ethan G., Ying Du, Stephanus T. Malherbe, Smitha Shankar, Jackie Braun, Joe Valvo, Katharina Ronacher, et al. 2017. "Host Blood RNA Signatures Predict the Outcome of Tuberculosis Treatment." Tuberculosis 107 (December): 48-58. https://dx.doi.org/10.1016/j.tube.2017.08.00410.1016/j.tube.2017.08.004
Tornheim_71: Tornheim, Jeffrey A., Anil K. Madugundu, Mandar Paradkar, Kiyoshi F. Fukutani, Artur TL Queiroz, Nikhil Gupte, Akshay N. Gupte et al. 2020. "Transcriptomic Profiles of Confirmed Pediatric Tuberculosis Patients and Household Contacts Identifies Active Tuberculosis, Infection, and Treatment Response Among Indian Children." The Journal of Infectious Diseases 221(10): 1647-1658. https://doi.org/10.1093/infdis/jiz63910.1093/infdis/jiz639
Tornheim_RES_25: Tornheim, Jeffrey A., Anil K. Madugundu, Mandar Paradkar, Kiyoshi F. Fukutani, Artur TL Queiroz, Nikhil Gupte, Akshay N. Gupte et al. 2020. "Transcriptomic Profiles of Confirmed Pediatric Tuberculosis Patients and Household Contacts Identifies Active Tuberculosis, Infection, and Treatment Response Among Indian Children." The Journal of Infectious Diseases 221(10): 1647-1658. https://doi.org/10.1093/infdis/jiz63910.1093/infdis/jiz639
Vargas_18: Vargas R, Abbott L, Bower D, Frahm N, Shaffer M, Yu WH. Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatment. PLoS Comput Biol. 2023;19(7):e1010770. http://dx.doi.org/10.1371/journal.pcbi.101077010.1371/journal.pcbi.1010770
Vargas_42: Vargas R, Abbott L, Bower D, Frahm N, Shaffer M, Yu WH. Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatment. PLoS Comput Biol. 2023;19(7):e1010770. http://dx.doi.org/10.1371/journal.pcbi.101077010.1371/journal.pcbi.1010770
Verhagen_10: Verhagen, L.M., Zomer, A., Maes, M. et al. A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children. BMC Genomics 14, 74 (2013). https://doi.org/10.1186/1471-2164-14-7410.1186/1471-2164-14-74
Walter_51: Walter, Nicholas D., Mikaela A. Miller, Joshua Vasquez, Marc Weiner, Adam Chapman, Melissa Engle, Michael Higgins, et al. 2016. "Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: A Case-Control Study with Systematic Cross-Classifier Evaluation." Journal of Clinical Microbiology 54 (2): 274-82. https://dx.doi.org/10.1128/JCM.01990-1510.1128/JCM.01990-15
Walter_PNA_119: Walter, Nicholas D., Mikaela A. Miller, Joshua Vasquez, Marc Weiner, Adam Chapman, Melissa Engle, Michael Higgins, et al. 2016. "Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: A Case-Control Study with Systematic Cross-Classifier Evaluation." Journal of Clinical Microbiology 54 (2): 274-82. https://dx.doi.org/10.1128/JCM.01990-1510.1128/JCM.01990-15
Walter_PNA_47: Walter, Nicholas D., Mikaela A. Miller, Joshua Vasquez, Marc Weiner, Adam Chapman, Melissa Engle, Michael Higgins, et al. 2016. "Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: A Case-Control Study with Systematic Cross-Classifier Evaluation." Journal of Clinical Microbiology 54 (2): 274-82. https://dx.doi.org/10.1128/JCM.01990-1510.1128/JCM.01990-15
Zak_RISK_16: Zak, Daniel E., Adam Penn-Nicholson, Thomas J. Scriba, Ethan Thompson, Sara Suliman, Lynn M. Amon, Hassan Mahomed, et al. 2016. "A Blood RNA Signature for Tuberculosis Disease Risk: A Prospective Cohort Study." The Lancet 387 (10035): 231222. https://dx.doi.org/10.1016/S0140-6736(15)01316-110.1016/S0140-6736(15)01316-1
Zhao_NANO_6: To be available when published
Details
Signature names are composed of the last name of the primary author, followed by a possible context for the signature, and ending with either the number of gene transcripts or genes in the signature, with respect to however it was described in the signature's original publication.
Possible signature contexts:
<blank>: TB vs LTBI or Healthy ControlsOD: Other diseases
HIV: Human Immunodeficiency Virus
PNA: Pneumonia
RISK: Risk of developing active TB
RES: Response to TB treatment
FAIL: Failure of TB treatment
Note that in some cases signatures will be positive identifiers of TB whereas others are negative identifiers; this should be taken into account when creating ROC curves and computing any AUC estimates.
Examples
data("TBsignatures")